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Prescriber Attitudes Toward NTI Drugs and Substitution Practices

Prescriber Attitudes Toward NTI Drugs and Substitution Practices

Caspian Mortensen Jan, 29 2026 0

Prescribers remain divided on substituting generic versions of narrow therapeutic index (NTI) drugs like warfarin, lithium, and levothyroxine. While generics are FDA-approved, many doctors worry about small changes in blood levels causing serious harm. State laws, patient safety, and emerging data are shaping how these swaps happen.

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